GABAA receptor modular-3
Product Specifications
CAS Number
3021554-08-2
Target
GABA Receptor
Related Pathways
Neuroscience|||Membrane transporter/Ion channel
Bioactivity
Compound S28, also known as GABAA receptor modulator-3, regulates the (?-aminobutyric acid) A receptor (GABAA receptor), exhibiting EC50 values of 56 nM for the ?1?2?2 subtype and 10 nM for the ?4?3? subtype. In rats, it demonstrates favorable pharmacokinetic properties and slight toxicity. The threshold dose for loss of righting reflex (LORR) in rats is 23.3 ?mol/kg. Furthermore, Compound S28 shows potential to alleviate postpartum depression.
Smiles
C[C@@]12[C@]([C@]3([C@@]([C@@]4([C@](CC3)(C[C@](C)(O)CC4)[H])[H])(CC1)[H])[H])(CC[C@@H]2C(CN5C(=O)N(N=C5)C=6C=C(F)N=C(F)C6)=O)[H]
Molecular Formula
C28H36F2N4O3
Molecular Weight
514.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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