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Hit 14

Product Specifications

CAS Number

440338-68-1

Target

Akt, CXCR

Related Pathways

Immunology/Inflammation, PI3K/Akt/mTOR signaling, Autophagy, Cytoskeletal Signaling, GPCR/G Protein

Bioactivity

Hit 14, a CXCR4 (C-X-C chemokine receptor type 4) inhibitor, demonstrates an IC50 of 254 nM. It inhibits migration and invasion of MDA-MB-231 cells and suppresses Akt phosphorylation, exhibiting anti-inflammatory activity. Furthermore, Hit 14 improves ear swelling and damage in a mouse model.

Smiles

O=S(=O)(NCC1OCCC1)C2=CC=C(OC3=CC=C(C=C3)S(=O)(=O)NCC4OCCC4)C=C2

Molecular Formula

C22H28N2O7S2

Molecular Weight

496.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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