Hit 14
Product Specifications
CAS Number
440338-68-1
Target
Akt|||CXCR
Related Pathways
Immunology/Inflammation|||PI3K/Akt/mTOR signaling|||Autophagy|||Cytoskeletal Signaling|||GPCR/G Protein
Bioactivity
Hit 14, a CXCR4 (C-X-C chemokine receptor type 4) inhibitor, demonstrates an IC50 of 254 nM. It inhibits migration and invasion of MDA-MB-231 cells and suppresses Akt phosphorylation, exhibiting anti-inflammatory activity. Furthermore, Hit 14 improves ear swelling and damage in a mouse model.
Smiles
O=S(=O)(NCC1OCCC1)C2=CC=C(OC3=CC=C(C=C3)S(=O)(=O)NCC4OCCC4)C=C2
Molecular Formula
C22H28N2O7S2
Molecular Weight
496.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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