(R) -Vorbipiprant
Product Specifications
CAS Number
2502965-92-4
Target
Prostaglandin Receptor
Related Pathways
Immunology/Inflammation|||GPCR/G Protein
Bioactivity
(R) -Vorbipiprant ((R) -CR6086) is an orally effective antagonist of the prostaglandin E2 receptor 4 (EP4), demonstrating a Ki of 16.6 nM for human EP4. It inhibits the production of cAMP induced by PGE2, with an IC50 of 22 nM. Additionally, (R) -Vorbipiprant exhibits immunomodulatory and antiangiogenic activities, having shown potential to alleviate collagen-induced arthritis in mice.
Smiles
N(C(=O)[C@@H]1N(CC2=CC=C(C(F)(F)F)C=C2)CCC3(C1)CC3)C4(CC4)C5=CC=C(C(O)=O)C=C5
Molecular Formula
C26H27F3N2O3
Molecular Weight
472.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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