AN317
Product Specifications
CAS Number
946074-35-7
Target
AChR
Related Pathways
Neuroscience
Bioactivity
AN317 is a selective agonist for the nicotinic acetylcholine receptor (nAChR) containing α6β2, with dissociation constants (Ki) of 6.2 nM and 4.1 nM for the α6/α3β2β3 and α4β2 receptor subtypes, respectively. It induces dopamine release in rat striatal synaptosomes, enhances the activity of dopaminergic neurons in the substantia nigra, and exhibits protective effects against the dopaminergic neurotoxin MPP+ in rat neurons. AN317 also demonstrates favorable pharmacokinetic properties in rats and permeability across the blood-brain barrier (BB) .
Smiles
N=1C=CC=C(C1)N2CC3N(C)C(C2)CCC3
Molecular Formula
C13H19N3
Molecular Weight
217.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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