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WIZ degrader 1

Product Specifications

CAS Number

2839552-68-8

Target

Histone Methyltransferase|||Others

Related Pathways

Others|||Chromatin/Epigenetic

Bioactivity

WIZ degrader 1 (Compound 141) is a degrader of the wide-interval zinc-finger motif (WIZ) with an AC50 of 2 nM. It can induce the expression of fetal hemoglobin (HbF), exhibiting an EC50 value of 6 mM. WIZ degrader 1 is used in the research of genetic blood disorders.

Smiles

C(C1=CC2=C(C=NN2C=C1)N3C(=O)NC(=O)CC3)[C@H]4C[C@H](C)N(CC5CCC(F)(F)CC5)CC4

Molecular Formula

C25H33F2N5O2

Molecular Weight

473.56

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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