Antitumor agent-171

Product Specifications

CAS Number

3003004-76-7

Target

Wnt/beta-catenin

Related Pathways

Stem Cells|||Cytoskeletal Signaling

Bioactivity

Antitumor agent-171 (Compound 35) acts as an inhibitor of the ?-catenin/BCL9 interaction, with an IC50 of 1.61 ?M. It suppresses the expression of the axin2 gene, demonstrating an IC50 value of 0.84 ?M, and exhibits high affinity for ?-catenin with a Kd of 0.63 ?M. Additionally, Antitumor agent-171 inhibits the viability of HCT116 cells with an IC50 of 4.39 ?M. It activates T cells, enhances antigen presentation, and shows antitumor activity and favorable pharmacokinetic properties in murine models.

Smiles

N(CC1=CC=C(C=C1)C=2C=NNC2)(C(N[C@@H]3CN(CCC3)C4=CC(OC(C(NCC(=O)N5CC[C@H](O)C5)=O)(C)C)=CC=C4)=O)C6CC6

Molecular Formula

C35H45N7O5

Molecular Weight

643.78

Shipping Conditions

Cool pack

Storage Temperature

-20°C