HRS 4642
Product Specifications
CAS Number
2836263-09-1
Target
MEK, Kras, ERK, Ras
Related Pathways
MAPK
Purity
0.9917
Bioactivity
HRS 4642 is a long-acting, selective KRAS G12D inhibitor with a Kd value of 0.083 nM. It inhibits phosphorylation of downstream MEK and ERK proteins, exhibiting antitumour activity. HRS 4642 reduces target lesions and, when used alone or in combination with Carfilzomib, remodels the tumour microenvironment towards an immunocompetent state.
Smiles
C(OC=1N=C2C3=C(N1)C(F)=C(N=C3OC[C@]4(N2C[C@@]5(N[C@]4(CC5)[H])[H])[H])C=6C7=C(C=CC(F)=C7CC)C=C(O)C6)[C@@]89N(C[C@H](F)C8)CCC9
Molecular Formula
C34H35F3N6O3
Molecular Weight
632.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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