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P2Y14R antagonist 1

Product Specifications

CAS Number

2728291-29-8

Target

NOD-like Receptor (NLR), P2Y Receptor

Related Pathways

Neuroscience, GPCR/G Protein, Immunology/Inflammation

Purity

0.9888

Bioactivity

P2Y14R antagonist 1 (compound I-17) is a selective and potent P2Y14R antagonist (IC50=0.6 nM) with oral activity and good bioavailability that inhibits monosodium urate-induced inflammatory response in acute gouty arthritis by reducing inflammatory factor release via the NLRP3/GSDMD signaling pathway and cellular pyroptosis.

Smiles

O=C(NC=1C=CC=2N=CNC2C1)COC3=CC=C(Br)C=C3

Molecular Formula

C15H12BrN3O2

Molecular Weight

346.18

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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