P2Y14R antagonist 1
Product Specifications
CAS Number
2728291-29-8
Target
NOD-like Receptor (NLR) |||P2Y Receptor
Related Pathways
Neuroscience|||GPCR/G Protein|||Immunology/Inflammation
Purity
0.9888
Bioactivity
P2Y14R antagonist 1 (compound I-17) is a selective and potent P2Y14R antagonist (IC50=0.6 nM) with oral activity and good bioavailability that inhibits monosodium urate-induced inflammatory response in acute gouty arthritis by reducing inflammatory factor release via the NLRP3/GSDMD signaling pathway and cellular pyroptosis.
Smiles
O=C(NC=1C=CC=2N=CNC2C1)COC3=CC=C(Br)C=C3
Molecular Formula
C15H12BrN3O2
Molecular Weight
346.18
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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