BPR5K230
Product Specifications
CAS Number
3029897-97-7
Target
TAM Receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
BPR5K230 is a dual inhibitor of the receptor tyrosine kinases MER and AXL, exhibiting IC50 values of 4.1 nM and 9.2 nM, respectively. It inhibits the proliferation of Ba/F3-MER cells with an IC50 of 5 nM. BPR5K230 demonstrates favorable pharmacokinetics in mice and displays anti-inflammatory and antitumor effects in mouse models against 4T1, MDA-MB-231, MC38, and Hepa1-6.
Smiles
O=C(NC1=CC=C(OC=2N=CN=C3OC(C=4C=NN(C4)C)=C(C5=CC=CC(=C5)CN(C)C)C23)C=C1)C6=CC=CN(C6=O)C7=CC=C(F)C=C7
Molecular Formula
C37H30FN7O4
Molecular Weight
655.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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