BPR5K230
Product Specifications
CAS Number
3029897-97-7
Target
TAM Receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
BPR5K230 is a dual inhibitor of the receptor tyrosine kinases MER and AXL, exhibiting IC50 values of 4.1 nM and 9.2 nM, respectively. It inhibits the proliferation of Ba/F3-MER cells with an IC50 of 5 nM. BPR5K230 demonstrates favorable pharmacokinetics in mice and displays anti-inflammatory and antitumor effects in mouse models against 4T1, MDA-MB-231, MC38, and Hepa1-6.
Smiles
O=C(NC1=CC=C(OC=2N=CN=C3OC(C=4C=NN(C4)C)=C(C5=CC=CC(=C5)CN(C)C)C23)C=C1)C6=CC=CN(C6=O)C7=CC=C(F)C=C7
Molecular Formula
C37H30FN7O4
Molecular Weight
655.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV688391 1.0 µg DNA
GLTP Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details 
K3891707 1.0 µg DNA
Fzd4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
Sign In for Pricing
View Details 
A06035-1-Fluoro550 100 µg/Vial
Anti-TOX3 Antibody Picoband® Fluoro550 Conjugated
Sign In for Pricing
View Details 
16249154 3x 1.0 µg DNA
CLCF1 CRISPR All-in-one AAV vector set (with saCas9)(Mouse)
Sign In for Pricing
View Details