HVH-2930
Product Specifications
CAS Number
3034605-72-3
Target
Survivin, EGFR, HSP, Akt
Related Pathways
PI3K/Akt/mTOR signaling, JAK/STAT signaling, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, Metabolism
Bioactivity
HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90) . It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 μM and 4.42 μM, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.
Smiles
O=C(NC=1C=CC=2C(=NN(C2C1)CCC3CCN(C)CC3)C)C4=CC=C5OC(C=CC5=C4OC)(C)C
Molecular Formula
C29H36N4O3
Molecular Weight
488.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K0073903 1.0 µg DNA
ALG10 sgRNA CRISPR Lentivector (Human) (Target 2)
Sign In for Pricing
View Details LV725665 1.0 µg DNA
FRA3C Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
Sign In for Pricing
View Details