HVH-2930
Product Specifications
CAS Number
3034605-72-3
Target
Survivin|||EGFR|||HSP|||Akt
Related Pathways
PI3K/Akt/mTOR signaling|||JAK/STAT signaling|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Apoptosis|||Metabolism
Bioactivity
HVH-2930 is an inhibitor of Heat Shock Protein 90 (HSP90) . It suppresses the cell viability of BT474 (Trastuzumab sensitive) and JIMT-1 (Trastuzumab resistant) by downregulating HSP90 client proteins such as HER2, p-HER2, AKT, p-AKT, cyclin D1, and survivin, with IC50 values of 6.86 ?M and 4.42 ?M, respectively. Additionally, HVH-2930 demonstrates antitumor efficacy in a mouse model and exhibits favorable pharmacokinetic properties in vivo.
Smiles
O=C(NC=1C=CC=2C(=NN(C2C1)CCC3CCN(C)CC3)C)C4=CC=C5OC(C=CC5=C4OC)(C)C
Molecular Formula
C29H36N4O3
Molecular Weight
488.62
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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