PAWI-2
Product Specifications
CAS Number
1448427-02-8
Target
Kras, Apoptosis, IκB/IKK, Caspase, MDM-2/p53, Ras, Wnt/beta-catenin
Related Pathways
Apoptosis, MAPK, NF-κB, Cytoskeletal Signaling, Proteases/Proteasome, Stem Cells
Bioactivity
PAWI-2 functions as both a p53 activator and a Wnt inhibitor. It suppresses β3-KRAS signaling independently of KRAS and selectively inhibits the phosphorylation of TBK1. Additionally, PAWI-2 triggers apoptosis (activation of caspase-3/7) and induces PARP cleavage. It facilitates the translocation of retinoblastoma protein into the nucleus, leading to G2/M cell cycle arrest. PAWI-2 reverses the cancer stem cell-like properties of KRAS-dependent human pancreatic cancer stem cells (hPCSC) and overcomes drug resistance. Moreover, it inhibits the growth of hPCSC tumors in an orthotopic xenograft mouse model.
Smiles
O=C1N(C2=CC=C(C=C2)S(=O)(=O)N3C=4C=CC=CC4N(C)CC3)CCC1
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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