Antitumor agent-172
Product Specifications
CAS Number
3027905-74-1
Target
Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling, Stem Cells
Bioactivity
Antitumor agent-172 (Compound 28) acts as an inhibitor of the β-catenin/BCL9 interaction, featuring an IC50 of 3.92 μM. This compound exhibits high affinity for β-catenin, with a Kd of 82 nM. Furthermore, Antitumor agent-172 activates T cells, enhances antigen presentation, and demonstrates antitumor activity along with favorable pharmacokinetic properties in murine models.
Smiles
N(CC1=CC=C(C=C1)C=2C=NNC2)(C(N[C@H]3CN(CCC3)C4=CC(OC(C(NCC(=O)N5C(CCN)CCC5)=O)(C)C)=CC=C4)=O)C6CC6
Molecular Formula
C37H50N8O4
Molecular Weight
670.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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