IGF-1R modulator 1
Product Specifications
CAS Number
2375424-89-6
Target
EGFR, Trk receptor, IGF-1R
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB) . This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.
Smiles
O=C1NC(=O)N(C2=CC=C(OC=3C=CC=CC3)C(=C2)C)C(=O)N1C=4C=CC=CC4
Molecular Formula
C22H17N3O4
Molecular Weight
387.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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