Glucocorticoid receptor modulator 3
Product Specifications
CAS Number
2688785-13-7
Target
Glucocorticoid Receptor
Related Pathways
Endocrinology/Hormones
Bioactivity
Glucocorticoid receptor modulator3 (Payload 6) is a thioester-based modulator of the glucocorticoid receptor, exhibiting a potent IC50 value of 0.6 nM. This compound is deactivated through rapid hepatic metabolism, minimizing systemic exposure of its unconjugated active payload. Glucocorticoid receptor modulator3 is suitable for development in antibody-drug conjugates (ADCs) targeted at autoimmune diseases.
Smiles
O(C(=O)C1=CC(N)=C(F)C=C1)[C@@]2(C(SCF)=O)[C@]3(C)[C@@](C[C@H]2C)([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]
Molecular Formula
C29H32F3NO5S
Molecular Weight
563.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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