O-Carboranylphenoxyacetanilide
Product Specifications
CAS Number
2260545-92-2
Target
HIF/HIF Prolyl-Hydroxylase, HSP
Related Pathways
Chromatin/Epigenetic, Cytoskeletal Signaling, Metabolism
Bioactivity
O-Carboranylphenoxyacetanilide is an HIF-1α inhibitor that suppresses the activation of HIF-1α. It inhibits the transcriptional activity of HIF in HeLa cells (IC50: 0.74 μM) and also suppresses the molecular chaperone activity of HSP60 as well as the HSP60 ATPase activity.
Smiles
O=C(NC1=CC(=CC=C1O)B(O)O)COC2=CC=C(C=C2)C3456[BH]789[BH]%10%11%12[BH]%13%149[BH]%10%15%16[BH]%11%17%18[BH]%1276[BH]%17%195[BH]%20%214[BH]%13%15([BH]%148%203)[CH]%16%18%19%21
Molecular Formula
C16H24B11NO5
Molecular Weight
429.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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