SLF80821178 hydrochloride

SLF80821178 hydrochloride is an orally active anticancer compound that effectively targets the inhibitory function of Spns2 (sphingosine-1-phosphate transporter) and can significantly reduce the release of sphingosine-1-phosphate (S1P) in HeLa cells. Has an IC50 value of 51 nM. Furthermore, SLF80821178 hydrochloride effectively reduced circulating lymphocyte levels in a mouse model without significant effects on plasma S1P levels.