CCR1 antagonist 12
Product Specifications
CAS Number
921208-19-7
Target
CCR
Related Pathways
Immunology/Inflammation, GPCR/G Protein, Microbiology/Virology
Bioactivity
CCR1 antagonist12 (Compound 12) is an antagonist of CCR1, exhibiting an IC50 of 3 nM against human CCR1. It inhibits the chemotaxis through pores induced by CCL3, with an IC50 of 0.009 μM. Additionally, CCR1 antagonist12 demonstrates favorable pharmacokinetic properties in a rat model.
Smiles
O=C(C=CC1=CC(OC)=C(Cl)C=C1NC(=O)C)N2CC3N(CC4=CC=C(F)C=C4)C(COC3)C2
Molecular Formula
C25H27ClFN3O4
Molecular Weight
487.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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