PROTAC CYP1B1 degrader-2
Product Specifications
CAS Number
2836297-26-6
Target
PROTACs, Cytochromes P450
Related Pathways
Metabolism, PROTAC
Bioactivity
PROTAC CYP1B1 degrader-2 (compound PV2), a VHL (von Hippel - Landau) E3 ligase-based degrader of CYP1B1, exhibits a DC50 of 1.0 nM after 24 hours in A549/Taxol cells. Furthermore, it effectively inhibits the growth, migration, and invasion of A549/Taxol cells.
Smiles
O(CCCCCCCC(N[C@H](C(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1)[C@@](C)(C)C)=O)C4=C(C=CC=C4)C=5N=C(SC5)C=6N=C(NC7=CC=C(Cl)C=C7)SC6
Molecular Formula
C49H56ClN7O5S3
Molecular Weight
954.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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