GSK-3? inhibitor 17
Product Specifications
CAS Number
2521624-67-7
Target
GSK-3
Related Pathways
Stem Cells|||PI3K/Akt/mTOR signaling
Bioactivity
GSK-3? Inhibitor 17 (compound 5 n) reduces the expression of p-p65 and KIM-1 proteins in a dose-dependent manner (16, 32, 64 µM) induced by cisplatin. Additionally, at a concentration of 32 µM, it decreases the levels of TNF-?, IL-1?, IL-6, and MCP-1 mRNA in an acute kidney injury (AKI) model of HK-2 cells triggered by cisplatin.
Smiles
O=C(OC)C=1SC(=CC1)S(=O)(=O)NC=2C=CC(=CC2)C3=NC(=NO3)C=4C=CN=C(C4)NC5=CC=C(OC(F)(F)F)C=C5
Molecular Formula
C26H18F3N5O6S2
Molecular Weight
617.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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