MT-1207

MT-1207 is a selective antagonist of adrenergic ?1 and 5-HT2A receptors with oral activity. It exhibits IC50 values of <0.1 nM for ?1A, 0.15 nM for ?1B, 1.40 nM for ?1D, and 0.27 nM for 5-HT2A. In the 2K2C rat model, MT-1207 effectively reduces blood pressure (BP) without impairing renal function. As a multitarget inhibitor, MT-1207 has potential for research in vasodilation.