C3N-Dbn-Trp2
Product Specifications
CAS Number
2631659-57-7
Target
P-gp
Related Pathways
Neuroscience|||Membrane transporter/Ion channel
Bioactivity
C3N-Dbn-Trp2 is an inhibitor of the ATP-binding cassette transporter ABCB1. It inhibits the efflux of Rhodamine 123 mediated by ABCB1 in HEK293T and HCT-15 cells, with IC50 values of 5.9 µM and 2.2 µM, respectively. Additionally, C3N-Dbn-Trp2 inhibits the efflux of Doxorubicin, thereby enhancing the cytotoxicity of Doxorubicin in cells expressing ABCB1.
Smiles
C([C@]12[C@](N3[C@@](C1)(C(=O)N[C@@H](CC=4C=5C(NC4)=CC=CC5)C3=O)[H])(N(CC6=CC=CC=C6)C=7C2=CC=CC7)[H])C8=CC=CC=C8
Molecular Formula
C36H32N4O2
Molecular Weight
552.66
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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