RWJ-58643
Product Specifications
CAS Number
287183-00-0
Target
Others, Serine Protease
Related Pathways
Others, Proteases/Proteasome
Bioactivity
RWJ-58643 is a β-trypsin and trypsin inhibitor used in studies to inhibit allergic inflammatory conditions. The compound was effective in reducing nasal allergy symptoms, eosinophil infiltration, and interleukin-5 (IL-5) levels at a lower dose (100 mg) . However, at higher doses (300 mg and 600 mg), an increase in eosinophils and elevated IL-5 levels were observed, showing a clear dose-dependent response.
Smiles
C(C(NC(=O)[C@H]1N(C(C)=O)C[C@H](O)C1)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3
Molecular Formula
C20H26N6O4S
Molecular Weight
446.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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