SIC-19
Product Specifications
CAS Number
713112-69-7
Target
SIK
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
SIC-19, a SIK2 inhibitor, functions by promoting the degradation of SIK2 protein via the ubiquitination pathway. It inhibits the growth of cancer cells and sensitizes cells, ovarian cancer organoids, and xenograft models to PARP inhibitors (such as Olaparib) .
Smiles
O=C(NC(=S)NNC(=O)C1=C(SC(=C1C2=CC=C(OC)C(OC)=C2)C)NC(=O)C=3C=CC=CC3)C=4C=CC=CC4
Molecular Formula
C29H26N4O5S2
Molecular Weight
574.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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