COB-187
Product Specifications
CAS Number
1862177-86-3
Target
GSK-3
Related Pathways
PI3K/Akt/mTOR signaling, Stem Cells
Bioactivity
COB-187 is an effective, ATP-competitive, selective inhibitor of GSK-3β. It inhibits GSK-3 through a reversible, cysteine (Cys) -199 dependent mechanism. Additionally, COB-187 suppresses the production of cytokines induced by LPS and the production of CXCL10 triggered by the SARS-CoV-2 spike protein.
Smiles
S=C1SCC(O)(C=2C=CC=CC2)N1CC=3C=CN=CC3
Molecular Formula
C15H14N2OS2
Molecular Weight
302.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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