GQN-B37-E
Product Specifications
CAS Number
2982663-28-3
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
GQN-B37-E is an effective selective binder and inhibitor of MCL-1. It binds to the BH3-binding domain of MCL-1. GQN-B37-E demonstrates binding affinity for MCL-1 within the sub-micromolar range (Ki= 0.6 μM), yet shows negligible binding to BCL-2 or BCL-XL.
Smiles
C(=C/C(N[C@@H](CC=1C=2C(NC1)=CC=CC2)C(O)=O)=O)\C=3C(=NN(C3)C4=CC(Cl)=CC=C4)C5=CC=C(O)C=C5
Molecular Formula
C29H23ClN4O4
Molecular Weight
526.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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