MTX-531
Product Specifications
CAS Number
2791417-66-6
Target
PI3K, PPAR, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Angiogenesis, JAK/STAT signaling, Metabolism
Bioactivity
MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 nM and 1.1-233 nM (PI3Kα, PI3Kβ...), respectively. It also acts as a weak agonist of PPARγ, with an EC50 of 3.4 μM in 293H cells.
Smiles
N([C@H](C)C1=CC=CC=C1)C=2C3=C(C=CC(=C3)C=4C=C(NS(C)(=O)=O)C(Cl)=NC4)N=CN2
Molecular Formula
C22H20ClN5O2S
Molecular Weight
453.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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