UNC8153
Product Specifications
CAS Number
2929304-60-7
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
UNC8153 is a selective degrader of the nuclear receptor binding SET domain-containing 2 (NSD2), with a binding Kd of 24 nM. It effectively reduces NSD2 protein levels and the dimethylation of lysine 36 on histone 3 (H3K36me2) chromatin. Its simple warhead promotes proteasome-dependent degradation of NSD2 through a novel mechanism.
Smiles
O=C(NC1=CC=C(C=C1)C(=O)NCCCCCCN)C2=CC=C(C=C2)CN(C(=O)C3=CC=C4NC(=O)COC4=C3)C5CC5
Molecular Formula
C33H37N5O5
Molecular Weight
583.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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