Prexasertib lactate
Product Specifications
CAS Number
2781996-46-9
Target
DNA/RNA Synthesis, Chk, Apoptosis
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Apoptosis
Bioactivity
Prexasertib lactate is the lactate salt form of Prexasertib and functions as a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of less than 1 nM. It also inhibits CHK2 (IC50 = 8 nM) and RSK1 (IC50 = 9 nM) . This compound induces double-strand DNA breaks and replication stress, leading to apoptosis (cell death), and exhibits antitumor activity.
Smiles
[C@@H](C(O)=O)(C)O.O(CCCN)C1=C(C(OC)=CC=C1)C2=CC(NC=3C=NC(C#N)=CN3)=NN2
Molecular Formula
C21H25N7O5
Molecular Weight
455.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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