KT-333
Product Specifications
CAS Number
2502186-79-8
Target
STAT|||Molecular Glues
Related Pathways
JAK/STAT signaling|||Stem Cells|||PROTAC
Purity
0.9812
Bioactivity
KT-333 is a potent, highly selective, heterobifunctional small molecule degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, including hematologic malignancies and solid tumors.KT-333 specifically binds to STAT3 proteins at one end of the spectrum, and binds to the E3 ubiquitin ligase, VHL, at the other end.
Smiles
C(N[C@H](COC1=C(Cl)C(CCCC(N[C@H](C(=O)N2[C@H](C(N[C@@H](C)C3=CC=C(C=C3)C4=C(C)N=CS4)=O)C[C@@H](O)C2)C(C)(C)C)=O)=CC=C1)CCC(N)=O)(=O)[C@H]5N6[C@](CC5)(CCN(C(C)=O)C[C@H](NC(=O)C7=CC=8C(N7)=CC=C(C(P(=O)(O)O)=O)C8)C6=O)[H]
Molecular Formula
C60H74ClN10O14PS
Molecular Weight
1257.78
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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