PX20606
Product Specifications
CAS Number
1268245-19-7
Target
FXR
Related Pathways
Metabolism
Bioactivity
PX20606 is an orally active farnesoid X receptor (FXR) agonist, demonstrating EC50 values of 220 nM (mFXR) and 50 nM (hFXR) in Gal4-FXR assays. It induces the expression of the tumor suppressor gene NDRG2 and inhibits tumor growth and metastasis in a mouse HCC model. Additionally, PX20606 exhibits hepatoprotective properties.
Smiles
O=C(O)C1=CC=C(C=C1)C2CC2C3=CC=C(OCC=4C(=NOC4C5CC5)C=6C(Cl)=CC=CC6Cl)C=C3Cl
Molecular Formula
C29H22Cl3NO4
Molecular Weight
554.85
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/217697458711429124/T88353
Available Sizes
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