TD114-2
Product Specifications
CAS Number
436866-52-3
Target
GSK-3
Related Pathways
PI3K/Akt/mTOR signaling|||Stem Cells
Bioactivity
TD114-2 (compound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3? (GSK-3?) with an IC50 of 48 nM. It forms a hydrogen bond with Arginine 141 (ARG141) in GSK-3?, an amino acid often found as a negatively charged residue in other kinases, contributing to its high selectivity. TD114-2 is applicable for research on diabetes, neurodegenerative diseases, and other conditions related to GSK-3?.
Smiles
O=C1NC(=O)C=2C3=CN(C=4C=CC=CC34)CCOCCOCCOCCOCCN5C=C(C=6C=CC=CC65)C12
Molecular Formula
C30H31N3O6
Molecular Weight
529.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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