SpiD3
Product Specifications
CAS Number
3033533-25-1
Target
NF-κB, Apoptosis
Related Pathways
Apoptosis, NF-κB
Purity
0.9915
Bioactivity
SpiD3 is an antitumor spirocyclic dimer with the advantage of being independent of TME (tumor microenvironment) stimulation. It induces apoptosis in chronic lymphocytic leukemia (CLL) cells, inhibits NF-κB activation, upregulates the UPR (unfolded protein response), and suppresses protein synthesis. It can be used to study BTK-mutated CLL.
Smiles
O=C1OC2(C(=O)N(C=3C=CC=CC32)CCCN4C(=O)C5(OC(=O)C(=C)C5)C=6C=CC=CC64)CC1=C
Molecular Formula
C27H22N2O6
Molecular Weight
470.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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