PROTAC EGFR degrader 10
Product Specifications
CAS Number
3034244-56-6
Target
PROTACs, EGFR, FAK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Cytoskeletal Signaling, JAK/STAT signaling, PROTAC
Bioactivity
PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.
Smiles
O=C1NC(=O)C(C2=CC=C(C=C2)N3CCC(OCCN4CCN(CC4)C5CCN(C6=CC(OC)=C(C=C6CC)NC7=NC=C(Cl)C(=N7)NC8=CC=C(OC)C=C8N(C)S(=O)(=O)C)CC5)CC3)CC1
Molecular Formula
C49H65ClN10O7S
Molecular Weight
973.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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