BFC1103

BFC1103 is a small molecule compound that primarily interacts with a specific domain of Bcl-2, particularly its loop domain. This interaction causes a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homologous 3) domain and switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of either Bax or Bak, both of which are crucial proteins in the mitochondrial-mediated intrinsic apoptosis pathway. In mouse models, BFC1103 effectively inhibited lung metastasis of triple-negative breast cancer. BFC1103 can be used to study the role of Bcl-2 family proteins in cancer development and their impact on cancer cell survival and proliferation.