What is the catalog number for SN-398?

The catalog number for SN-398 is T88266.

What sizes are available for SN-398?

SN-398 is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does SN-398 come in?

SN-398 is available in 3 different pack sizes.

SN-398 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SN-398?

SN-398 is manufactured by Molfinity.

What is the estimated delivery time for SN-398?

Estimated delivery time for SN-398 is approximately 10 business day(s), depending on your location.

SN-398

Product Specifications

CAS Number

124623-00-3

Target

Topoisomerase

Related Pathways

DNA Damage/DNA Repair

Bioactivity

SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 μM) . SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells.