CDK8/19-IN-2
Product Specifications
CAS Number
3024381-54-9
Target
STAT, CDK
Related Pathways
Cell Cycle/Checkpoint, Stem Cells, JAK/STAT signaling
Bioactivity
CDK8/19-IN-2 (compound 12) is a potent inhibitor of cyclin-dependent kinases 8 and 19 (CDK8 and CDK19), exhibiting IC 50 values of 2.08 nM and 2.49 nM, respectively. This orally active compound is applicable in the research of acute myeloid leukemia (AML), breast cancer, and lymphoma.
Smiles
FC(F)C=1C(Br)=C(Br)C=C2C1N=C(N2C3CCOCC3)N4CCNCC4
Molecular Formula
C17H20Br2F2N4O
Molecular Weight
494.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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