Aftin-5
Product Specifications
CAS Number
1461717-05-4
Target
Beta Amyloid
Related Pathways
Neuroscience
Bioactivity
Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42) . It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.
Smiles
N(C)(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](CC)CO)=N1)C3=CC=CC=C3
Molecular Formula
C19H26N6O
Molecular Weight
354.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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