3-sucCA
Product Specifications
CAS Number
94159-47-4
Target
Others, Endogenous Metabolite, Antibacterial
Related Pathways
Others, Metabolism, Microbiology/Virology
Bioactivity
3-SucCA (3-Succinylated cholic acid), a bile acid derived from microbial sources, primarily functions as a lumen-restricted metabolite. It plays a crucial role in mitigating the progression of MAFL-MASH in mouse models by altering the gut microbiota composition, notably by enhancing the proliferation of Akkermansia muciniphila. Notably, lower levels of 3-sucCA have been observed in patients with biopsy-proven MAFLD.
Smiles
O[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCC(O)=O)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]4(C)[C@](C1)(C[C@H](OC(CCC(O)=O)=O)CC4)[H])[H])[H])[H]
Molecular Formula
C28H44O8
Molecular Weight
508.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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