3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles
Product Specifications
CAS Number
287196-91-2
Target
TGF-beta/Smad, MEK
Related Pathways
MAPK, Stem Cells
Bioactivity
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles serves as an inhibitor of both bone morphogenetic protein 2 (BMP2), with an IC50 value of 2.2 μM, and mitogen-activated protein kinase 1 (MEK1) . Additionally, this compound demonstrates anti-inflammatory and neuroprotective effects in an EAE mouse model.
Smiles
N#CC=1C(=O)NSC1NC=2C=CC=CC2C(F)(F)F
Molecular Formula
C11H6F3N3OS
Molecular Weight
285.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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