XOR/URAT1-IN-1
Product Specifications
CAS Number
2810137-86-9
Target
OAT, Xanthine Oxidase
Related Pathways
Metabolism, Membrane transporter/Ion channel
Bioactivity
Compound II15, known as XOR/URAT1-IN-1, serves as a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in a mouse model of acute hyperuricemia induced by potassium oxonate and hypoxanthine.
Smiles
O=C(O)C=1C=CC(=CC1O)C2=CN=CC(=C2)NC=3C=CC=C(Cl)C3
Molecular Formula
C18H13ClN2O3
Molecular Weight
340.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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