WRN inhibitor 8

3026502-95-1

DNA/RNA Synthesis

Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

WRN inhibitor 8 (Example 224), a potent inhibitor of WRN helicase, exhibits an IC50 of 48 nM. This compound is applicable in cancer research.

O(C=1C(C(N[C@H](/C=C/S(C)(=O)=O)C2CC2)=O)=CN=C(C(F)(F)C3CC3)N1)C4=CC=CC=C4

C22H23F2N3O4S

463.5

Cool pack

-20°C