GS-9770
Product Specifications
CAS Number
2306328-43-6
Target
HIV Protease
Related Pathways
Proteases/Proteasome, Microbiology/Virology
Bioactivity
GS-9770, an orally active HIV protease inhibitor, demonstrates a K i of 0.16 nM. It shows potent antiviral activity against both HIV-1 and HIV-2 strains, with EC 50 values ranging from 1.9 to 26 nM. GS-9770 is metabolically stable in human liver microsomes and displays favorable pharmacokinetic properties in Sprague Dawley rats.
Smiles
C(C(C(F)(F)F)(C)C)[C@]1(C(=O)N([C@H](COC(NC2(C(F)F)CC2)=O)C3=CC(=C(Cl)C=C3)C=4N(C(F)F)N=CN4)C(N)=N1)C5=CC=C(C=C5)C6=NN(N=C6)C7CC7
Molecular Formula
C35H34ClF7N10O3
Molecular Weight
811.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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