Antimalarial agent 38
Product Specifications
CAS Number
123580-46-1
Target
Parasite
Related Pathways
Microbiology/Virology
Bioactivity
Antimalarial agent 38 (Compound 1) demonstrates antiplasmodial activity by inhibiting multiple strains of Plasmodium falciparum, including the D6 strain, chloroquine-sensitive Thai strain, and chloroquine-resistant FcB1 and K1 strains, with IC 50 values of 0.5, 13, 1, and 13 ?M, respectively. This compound is non-cytotoxic to mammalian cells MCR58 (IC 50 >140 ?M) and enhances the survival rate in a Plasmodium yoelii nigeriensis-infected mouse model.
Smiles
O=C(OCC)COC=1C=C(C=CC1OC)C=2OC=3C=C(OCC(=O)N4CCN(CC5=CC=C(OC)C(OC)=C5OC)CC4)C=C(O)C3C(=O)C2
Molecular Formula
C36H40N2O12
Molecular Weight
692.71
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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