VNPP433-3β
Product Specifications
CAS Number
1630820-51-7
Target
Apoptosis, Androgen Receptor, MNK, Molecular Glues
Related Pathways
PROTAC, MAPK, Endocrinology/Hormones, Apoptosis
Bioactivity
VNPP433-3β acts as a molecular glue degrader, targeting the androgen receptor (AR) and its splice variants (AR-Vs) as well as MAP kinase-interacting serine/threonine protein kinase Mnk1/2. It effectively inhibits the proliferation of cancer cells LNCaP, C4-2B, and CWR22Rv1, with GI50 values of 0.2, 0.3, and 0.31 μM, respectively. Additionally, VNPP433-3β shows favorable pharmacokinetics in CD-1 mice and suppresses tumor growth in the CWR22Rv1 xenograft mouse model.
Smiles
C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@H](CC4)N5C=CN=C5)[H])[H])(CC=C2N6C=7C(N=C6)=CC=CC7)[H]
Molecular Formula
C29H34N4
Molecular Weight
438.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
111201O1-AAT 100 Tests
PE/XFD700 Anti-human CD112 Antibody *R2.525*
Sign In for Pricing
View Details 
MBS9328746-01 48 Well
Mouse POU domain, class 6, transcription factor 1, POU6F1 ELISA Kit
Sign In for Pricing
View Details MBS9328746-02 96 Well
Mouse POU domain, class 6, transcription factor 1, POU6F1 ELISA Kit
Sign In for Pricing
View Details MBS9328746-03 5x 96 Well
Mouse POU domain, class 6, transcription factor 1, POU6F1 ELISA Kit
Sign In for Pricing
View Details