Pan-RAS-IN-2
Product Specifications
CAS Number
3034673-92-9
Target
Ras, Molecular Glues
Related Pathways
MAPK, PROTAC, GPCR/G Protein
Bioactivity
Pan-RAS-IN-2 (compound 6A) is a molecular glue that specifically targets RAS molecules, exhibiting significant inhibitory activity on the proliferation of RAS-mutated cell lines. It forms a ternary complex with cyclophilin A (CYPA) and RAS (ON) proteins, which blocks the downstream binding of RAF to RAS, thereby exerting antitumor effects.
Smiles
O=C1OCC(C)(C)CC=2C3=CC(=CC=C3N(C2C=4C=C(C=NC4C(OC)C)N5CCN(C)CC5)CC)C=6N=C(SC6)CC(NC(=O)C7C(C)C7C)C(=O)N8NC1C9CC8C9
Molecular Formula
C46H60N8O5S
Molecular Weight
837.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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