TLR8 agonist 9
Product Specifications
CAS Number
3034750-61-0
Target
TLR
Related Pathways
Immunology/Inflammation
Bioactivity
TLR8 agonist9 (Compound II-77) functions as an agonist for Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. This compound is stable in human and mouse plasma and effectively induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist9 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 97%.
Smiles
O=C1C=CC(=O)N1CC2OCC(C(=O)N3CC4=CC(=CN=C4CC3)NC(=O)C5(C=6C=CC=7C=C(C(=O)N(CCO)CCC)CC(=NC7C6)N)CC5)CO2
Molecular Formula
C38H43N7O8
Molecular Weight
725.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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